References
- Palombo P, Fabrizi G, Ruocco V, et al. Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2007;20(4):199-210.
- Juturu V., Bowman J.P., Deshpande J. Overall skin tone and skin-lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers: A double- blind, placebo-controlled clinical trial. Clin. Cosmet. Investig. Dermatol. 2016;9:325–332.
- Feeney J., O’Leary N., Moran R., O’Halloran A.M., Nolan J.M., Beatty S., Young I.S., Kenny R.A. Plasma lutein and zeaxanthin are associated with better cognitive function across multiple domains in a large population-based sample of older adults: Findings from the Irish longitudinal study on aging. J. Gerontol. A. 2017;72:1431-1436 4. Ozawa Y., Sasaki M., Takahashi N., Kamoshita M., Miyake S., Tsubota K. Neuroprotective effects of lutein in the retina. Curr. Pharm. Des. 2012;18:51-56.
- Hininger IA, Meyer-Wenger A, Moser U, et al. No significant effects of lutein, lycopene or ẞ-carotene supplementation on biological markers of oxidative stress and LDL oxidizability in healthy adult subjects. J Am Coll Nutr. 2001;20:232-238
- Seddon JM, Anjani UA, Sperduto RD, Hiller R, Blair N, Burton TC, Farber MD, Gragoudas ES, Haller J, Miller DT, Yannuzzi LA, Willett W, The Eye Disease Case-Control Study Group Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. JAMA. 1994;272:1413-1420.
- Rock CL, Thornquist MD, Neuhouser ML, Kristal AR, Neumark-Sztainer D, Cooper DA, Patterson RE, Cheskin LJ. Diet and lifestyle correlates of lutein in the blood and diet. J Nutr. 2002;132:525S-530S. doi: 10.1093/jn/132.3.525S.
- Bowen, P.E.; Herbst-Espinosa, S.M.; Hussain, E.A.; Stacewicz-Sapuntzakis, M. Esterification does not impair lutein bioavailability in humans. J. Nutr. 2002, 132, 3668- 3673. [CrossRef]
- Landrum, J.; Bone, R.; Mendez, V.; Valenciaga, A.; Babino, D. Comparison of dietary supplementation with lutein diacetate and lutein: A pilot study of the effects on serum and macular pigment. Acta Biochim. Pol. 2012, 59, 167–169. [CrossRef] [PubMed]
- Norkus, E.P.; Norkus, K.L.; Dharmarajan, T.S.; Schierle, J.; Schalch, W. Serum lutein response is greater from free lutein than from esterified lutein during 4 weeks of supplementation in healthy adults. J. Am. Coll. Nutr. 2010, 29, 575–585. [CrossRef]
- Yoshizako, H.; Hara, K.; Takai, Y.; Kaidzu, S.; Obana, A.; Ohira, A. Comparison of macular pigment and serum lutein concentration changes between free lutein and lutein esters supplements in Japanese subjects. Acta Ophthalmol. 2016, 94, e411–e416. [CrossRef]
- Wu, L.; Huang, X.; Shi, K.; Tan, R. Bioavailability comparison of free and esterified lutein for layer hens. Braz. J. Poult. Sci. 2009, 11, 95–98. [CrossRef]
- Begoña Olmedilla-Alonso; Fernando Granado-Lorenci; Julio Castro-Feito; Carmen Herrero-Barbudo; Inmaculada Blanco-Navarro; Rocío Estévez-Santiago; Bioavailability of Lutein from Marigold Flowers (Free vs. Ester Forms): A Randomised Cross-Over Study to Assess Serum Response and Visual Contrast Threshold in Adults 14.Obana A, Gohto Y, Nakazawa R, Moriyama T, Gellermann W, Bernstein PS. Effect of an antioxidant supplement containing high dose lutein and zeaxanthin on macular pigment and skin carotenoid levels. Sci Rep. 2020 Jun 24;10(1):10262.
- Weigert G, Kaya S, Pemp B, Sacu S, Lasta M, Werkmeister RM, Dragostinoff N, Simader C, Garhöfer G, Schmidt-Erfurth U, Schmetterer L. Effects of lutein supplementation on macular pigment optical density and visual acuity in patients with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011 Oct 17;52(11):8174-8.
- Stringham JM, Stringham NT, O’Brien KJ. Macular Carotenoid Supplementation Improves Visual Performance, Sleep Quality, and Adverse Physical Symptoms in Those with High Screen Time Exposure. Foods. 2017 Jun 29;6(7):47. doi: 10.3390/foods6070047.
- Billy R. Hammond; Laura M. Fletcher; Franz Roos; Jonas Wittwer; Wolfgang Schalch;A Double-Blind, Placebo-Controlled Study on the Effects of Lutein and Zeaxanthin on Photostress Recovery, Glare Disability, and Chromatic Contrast, Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8583-8589.
- S Mehkri et.al,;The effects of lutein and zeaxanthin (Lute-gen®) supplementation, with and without natural mixed carotenoids on macular pigment optical density in healthy adult subjects: A randomized, double-blind, placebo-controlled study. International Journal of Ophthalmology Research, Volume 4, Issue 1, 2022, Page No. 1-5. 19. R. Cantrill et.al, Lutein Esters from Tagetes Erecta CTA 2016, 82nd JECFA – Chemical and Technical Assessment (CTA), 2016 – Page 1 of 5.
- EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS); Scientific Opinion on the re evaluation of lutein (E 161b) as a food additive. EFSA Journal 2011;9(5):2144. [25 pp.].
- Age-Related Eye Disease Study 2 (AREDS2) Research Group (2014). JAMA Ophthalmol. 132: 142-149.
- Hammond B, et al. (2014). Invest Ophthalmol Vis Sci. 55: 8583-8589
- U.S. Department of Agriculture, Agricultural Research Service. Nutrient Intakes from Food and Beverages: Mean Amounts Consumed per Individual, by Gender and Age, What We Eat in America, NHANES 2013-2014. 2016.